Novoprotein citations

Arthritis Research & Therapy
March 09 2017
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19

Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T cell activation.

Developmental & Comparative Immunology
August 01 2017
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73

Galectins are members of the lectin superfamily. They function as pattern recognition receptors in the innate immune system of vertebrates and invertebrates. A galectin homolog from the triangle sail mussel Hyriopsis cumingii (HcGal2) was cloned and characterized.

Proceedings of the National Academy of Sciences of the United States of America
March 14 2017
,
2017

Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases.

Journal of Bone and Mineral Research
January 04 2017
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32

Gorham-Stout disease (GSD) is a rare bone disorder characterized by aggressive osteolysis associated with lymphatic vessel invasion within bone marrow cavities. The etiology of GSD is not known and there is no effective therapy or animal model for the disease.

LWT - Food Science and Technology
February 28 2017
,
80

Effects of laccase-catalyzed cross-linking on the structure, gel properties and antioxidant activities of α-lactalbumin (α-LA) were investigated in the presence of ferulic acid (FA).

Cell Discovery
February 21 2017
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3

Plasminogen activation is involved in many processes within the central nervous system, including synaptic plasticity, neuroinflammation and neurodegeneration. However, the mechanisms that regulate plasminogen activation in the brain still remain unknown.

Spandidos Publications
February 07 2017
,
n/a

The use of personalized adoptive immunotherapy as a potential novel approach is promising in the treatment of tumors resistant to conventional therapies.

FPO: Driving IP Forward
February 02 2017
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A1

A method of determining the presence of autoimmune disease comprising the steps of: a) generating a glycosylation profile of glycoprotein of a subject; b) identifying a glycan biomarker from said glycosylation profile; c) quantifying relative abundance of said glycan biomarker; and d) determining

United States Patent Application 20170020964
January 26 2017
,
A1

An IL-15 heterodimeric protein, comprising: protein (I) and protein (II); wherein protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant; protein (II) is a second Fc variant, or is recombinantly produced by combining IL-15Rα or a variant thereof with

United States Patent Application 20170020964
January 26 2017
,
A1

A method of treating a mammalian subject with cancer comprising: (a) administering to said subject having a cancer or tumor a small molecule inhibitor of a target signaling molecule within the MEK/MAPK pathway, which inhibitor impairs T cell activation; and (b) administering to said subject a mol

Nature: Cell Biology
January 23 2017
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19

Bone metastases remain a serious health concern because of limited therapeutic options. Here, we report that crosstalk between ROR1–HER3 and the Hippo–YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion.

Inflamation Research
January 10 2017
,
66

Neutrophil chemotaxis plays an essential role in recruiting neutrophils to sites of inflammation. Neutrophil chemotaxis is suppressed both after exposure to lipopolysaccharide (LPS) in vitro and during clinical and experimental endotoxemia, leading to serious consequences.

Publicly Available Penn Disertations
December 1, 2016
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1586

Through rational drug design, much progress has been made to develop small molecules that specifically inhibit the oncogenic signaling pathways driving malignant growth.

Frontiers in Immunology
November 28, 2016
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7

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system.

Frontiers in Immunology
November 28, 2016
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7

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system.

Frontiers in Immunology
November 28, 2016
,
7

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system.

JCI Insight
December 8, 2016
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1(20)

Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic diseases.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Scientific Reports
December 13, 2016
,
6

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown.

Journal of Virology
November 16, 2016
,
90

Rabies still remains a public health threat in most parts of the world, and approximately 99% of the cases are transmitted by dogs. There is an urgent need to develop an efficacious and affordable vaccine to control canine-transmitted rabies in developing countries.

October 4, 2016
,
2016 4:33

Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP.

American Journal of Translational Research
September 15, 2016
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8.9

This study aimed to investigate the effects of exosomes derived from BM-MSCs transduced with let-7a on B16f10 cells and BM-MSCs. BM-MSCs were transduced with let-7a and the exosomes of them were isolated for further culture of B16f10 cells and BM-MSCs.

Lipids in Health and Disease
September 19, 2016
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15:161

Previous reports have suggested that advanced glycation end products (AGEs) participate in the pathogenesis of diabetic macroangiopathy.

Journal of Proteomics
September 23, 2016
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150

Apolipoproteins measured in plasma or serum are potential biomarkers for assessing metabolic irregularities that are associated with the development of cardiovascular disease (CVD). LC-MS/MS allows quantitative measurement of multiple apolipoproteins in the same sample run.

Journal of Proteomics
September 23, 2016
,
150

Apolipoproteins measured in plasma or serum are potential biomarkers for assessing metabolic irregularities that are associated with the development of cardiovascular disease (CVD). LC-MS/MS allows quantitative measurement of multiple apolipoproteins in the same sample run.