1:Eur. J. Neurosci.2011 Feb,33(4)
The precursor of the neurotrophin (NT) nerve growth factor (NGF) (proNGF) serves physiological functions distinct from its mature counterpart as it induces neuronal apoptosis through activation of a p...
2:J. Neurosci.2009 Nov 25,29(47)
Although mature neurotrophins are well described trophic factors that elicit retrograde survival signaling, the precursor forms of neurotrophins (i.e., proneurotrophins) can function as high-affinity ...
Recombinant Human ProNT-3
Recombinant Human precursor form of Neurotrophin-3/pro-NT3 is produced by our E. coli expression system.
Pro-Neurotrophin-3 (pro-NT3) is the precursor form of Neurotrophin-3. Pro-NT3 interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature NT3 selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner.
Howard L, et al. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism
PMID: 23633509, PMCID: PMC3640218