1:2012 Jun 15,

Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cdh1 and Pgr, and its influence on endometrial receptivity and embryo implantation.

BACKGROUNDFolate, one of the B vitamins, provides the one-carbon units required for methylation. Folate deficiency has been associated with many pathologies. However, much less is known about the effe...

2:2012 May 8,

ESR1 gene status correlates with estrogen receptor protein levels measured by ligand binding assay and immunohistochemistry.

The Estrogen Receptor (ER) is an established predictive marker for the selection of adjuvant endocrine treatment in early breast cancer. During the 1990s Immunohistochemistry (IHC) replaced cytosol ba...

3:Pharmacol Rep2012 Jan,64(1)

Effect of ESR1 and ESR2 gene polymorphisms on rheumatoid arthritis treatment with methotrexate.

Rheumatoid arthritis (RA) is a complex autoimmune disease with clinical prevalence in women. Moreover, women have poorer response to treatment than men. Possible reasons for gender differences in resp...

4:Exp. Dermatol.2012 May,21(5)

Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified.

Female pattern hair loss (FPHL) is a common disorder with a complex mode of inheritance. Although understanding of its etiopathogenesis is incomplete, an interaction between genetic and hormonal facto...

5:Endocrinology2012 Apr,153(4)

Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase.

Oviductal disease is a primary cause of infertility, a problem that largely stems from excessive inflammation of this key reproductive organ. Our poor understanding of the mechanisms regulating oviduc...

6:PLoS ONE2012,7(7)

Microsatellites in the Estrogen Receptor (ESR1, ESR2) and Androgen Receptor (AR) Genes and Breast Cancer Risk in African American and Nigerian Women.

Genetic variants in hormone receptor genes may be crucial predisposing factors for breast cancer, and microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes have been s...

7:2012 Jul 19,

Genetic variants of EGFR (142285G>A) and ESR1 (2014G>A) gene polymorphisms and risk of breast cancer.

Breast cancer is one of the most common cancers in women worldwide. The estrogen receptor alpha (ESR1) and epidermal growth factor receptor (EGFR) have been known to play a vital role in development a...

8:Epigenetics Chromatin2012 Aug 22,5(1)

Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene.

ABSTRACT: BACKGROUND: In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the...

9:Domest. Anim. Endocrinol.2012 Sep 21,

Role of estrogen receptor-? (ESR1) and the type 1 insulin-like growth factor receptor (IGFR1) in estradiol-stimulated proliferation of cultured bovine satellite cells.

Although the exact mechanism(s) by which estradiol (E(2)) enhances muscle growth in a number of species, including humans and cattle, is not known, E(2) treatment has been shown to stimulate prolifera...

10:Tsitol. Genet.2012 Jul-Aug,46(4)

[ESR1 gene allelic polymorphism analysis in population of Ukraine].

In this study analysis of single nucleotide polymorhisms A351G, C397T and number of TA-repeats in ESR1 gene among 199 healthy volunteers from Ukraine was performed. Data concerning genotypes and parti...

11:J. Bone Miner. Res.2012 Oct 16,

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPS associated with bone mineral density in premenopausal women.

Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined sample...

12:Asian Pac. J. Cancer Prev.2012,13(8)

Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis.

Background: Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 on estrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results. Methods: A ...

13:Infection2012 Oct 30,

Polymorphism of estrogen receptor alpha (ESR1) is associated with virological response to entecavir (ETV) in nucleoside-naïve adult patients with chronic hepatitis B.

INTRODUCTION: Polymorphisms in estrogen receptor alpha (ESR1) are reported to be associated with the susceptibility to persistent HBV infection, HBV liver cirrhosis and HBV-related hepatocellular carc...

14:Gynecol. Endocrinol.2012 Nov 2,

Estrogen receptor ? gene (ESR1) polymorphisms associated with idiopathic premature ovarian failure in Chinese women.

Objective: To evaluate the relationship between Estrogen receptor ? gene (ESR1) polymorphisms and idiopathic premature ovarian failure (POF) in Chinese women. Methods: 155 idiopathic POF and 150 healt...

15:Steroids2012 Nov 1,

Estrogen receptor ESR1 regulates the phospholipase C-inositol phosphate signaling in the hippocampus from rats in proestrous and estrous phases.

The aim of the present study was to investigate the involvement of estrogen receptors in the activation of phospholipase C (PLC)-phosphoinositide hydrolysis in the hippocampus from rats in estrous and...

16:Ann. Oncol.2012 Nov 6,

RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy.

BackgroundHormone and human epidermal growth factor receptor 2 (HER2) receptors are the most important breast cancer biomarkers, and additional objective and quantitative test methods such as messenge...

17:J. Assist. Reprod. Genet.2012 Nov 13,

Risk of premature ovarian failure is associated to the PvuII polymorphism at estrogen receptor gene ESR1.

PURPOSE: Estrogen plays an important role in the human reproductive system and it action is mediated mainly by two specific receptors: ? (ER?) and ? (ER?). There were described polymorphic variants in...

18:Genome Res.2012 Nov 21,

GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility.

Estrogen receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer oc...

19:Horm Behav2012 Nov 30,

ESR1 Polymorphisms, Daily Hassles, Anger Expression, and Depressive Symptoms in Adolescent Boys and Girls.

Studies reporting associations between genetic factors and mood-related traits have often been critized (i) for failing to take into account the role of the social environment in which individuals act...

20:Asian Pac. J. Cancer Prev.2012,13(10)

Menopausal Status Modifies Breast Cancer Risk Associated with ESR1 PvuII and XbaI Polymorphisms in Asian Women: a HuGE Review and Meta-analysis.

Background: Published data on the association between single nucleotide polymorphisms (SNPs) in the ESR1 gene and breast cancer susceptibility are inconclusive or controversial. The aim of this Human ...

Protein Name:Estrogen Receptor
Gene Name:ESR1 ESR NR3A1


Recombinant Human ER alpha/NR3A1
(CatNo. CE11)

Recombinant Human Estrogen Receptor is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Gln116) of Human ESR1 fused with a His tag at the N-terminus.

Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.