Prospect of IL-2, IL-7, IL-15 and IL-21 for HIV immune-based therapy.

Although highly active antiretroviral therapy (HAART) can effectively reduce the HIV replication, complete recovery of CD4(+) T cells does not always occur, even among patients with high virological control. Current researches on ?-chain cytokines have understood the biology and their crucial roles in initiating, maintaining, and regulating the immunologic homeostasis and the inflammatory processes. Due to the multiple functions such as the regulatory and effector cellular function in healthy and disease state, these molecules, their receptors, and their signal transduction pathways are promising candidates for therapeutic interference. The common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 are primary regulators of T cell homeostasis and thus have been considered prime immunotherapeutic candidates, both for increasing T cell levels/function and augmenting vaccine-elicited viral-specific T cell responses in immunocompromised AIDS patients. The Objective of this review is to update the role of the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 in HIV AIDS pathogenesis.

Zhong Nan Da Xue Xue Bao Yi Xue Ban2011 Nov,36(11).

Protein Name:IL-7
Gene Name:IL7


Recombinant Human IL-7
(CatNo. C086)

Recombinant Human Interleukin-7/IL-7 is produced with our E. coli expression system. The target protein is expressed with sequence (Asp26-His177) of Human IL-7.

Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.