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10ug50ug500ug1mg
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Recombinant Human Bone Morphogenetic Protein 2/BMP-2
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10ug/$150

50ug/$440

500ug/$1850

1mg/$2640

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Catalog#C012
SourceE. coli
DescriptionRecombinant Human Bone Morphogenetic Protein 2/BMP-2 is produced by our E. coli expression system. The target protein is expressed with sequence (Gln283-Arg396) of Human BMP-2.
NamesBone Morphogenetic Protein 2, BMP-2, Bone Morphogenetic Protein 2A, BMP-2A, BMP2, BMP2A
Accession #P12643
FormulationLyophilized from a 0.2 μM filtered solution of 50mM HAc
ShippingThe product is shipped at ambient temperature.
ReconstitutionAlways centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 50mM Acetic Acid.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
StorageLyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Biological ActivityRecombinant BMP-2 is fully biologically active when compared to standards.
ED50 is less than 50 ng/ml as determined by the cytolysis of MC3T3-E1 cells.
Specific Activity of 2.0 x 104 IU/mg
PurityGreater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
EndotoxinLess than 0.1 ng/µg (1 IEU/µg).
Amino Acid Sequence
MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQ TLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
BackgroundBone Morphogenetic Protein-2 (BMP-2) is one of the bone-growth regulatory factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of proteins. BMPs are synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form of BMP-2 can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
ReferencesWu T, et al. miR-30 family members negatively regulate osteoblast differentiation. PMID: 22253433, PMCID: PMC3293535 http://www.ncbi.nlm.nih.gov/pubmed/22253433