|Recombinant Human Amyloid ? A4 Precursor Protein-Binding Family A Member 3/APBA3|
|Description||Recombinant Human Amyloid ? A4 Precursor Protein-Binding Family A Member 3/APBA3 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Leu138) of Human APBA3 fused with a 6His tag at the C-terminus.|
|Names||Amyloid Beta A4 Precursor Protein-Binding Family A Member 3, Adapter protein X11Gamma, Neuron-Specific X11L2 Protein, Neuronal Munc18-1-Interacting Protein 3, Mint-3, APBA3, MINT3, X11L2|
|Formulation||Lyophilized from a 0.2 ?M filtered solution of 20mM PB ,150mM NaCl, pH 7.2|
|Shipping||The product is shipped at ambient temperature.|
|Reconstitution||Always centrifuge tubes before opening. Do not mix by vortex or pipetting.|
It is not recommended to reconstitute to a concentration less than 100 ?g/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Storage||Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.|
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
|Purity||Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.|
|Endotoxin||Less than 0.1 ng/?g (1 IEU/?g).|
|Amino Acid Sequence|
MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFE ALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEE PLEPAPRLLEHHHHHH
|Background||Amyloid ? A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-? and -? which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amyloid protein (APP) in vivo and may modulate processing of the ?-amyloid precursor protein (APP) and hence formation of ?-APP.|